Helicobacter pylori non-cytotoxic genotype enhances mucosal gastrin and mast cell tryptase
| Autor: | Mario Plebani, Daniela Basso, Massimo Rugge, Filippo Navaglia, F. Di Mario, L Brigato |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Gastroenterology Polymerase Chain Reaction chemistry.chemical_compound Mast Cells Gastrin biology digestive oral and skin physiology Serine Endopeptidases General Medicine Middle Aged Somatostatin medicine.anatomical_structure Female Gastritis medicine.symptom Histamine Research Article Adult medicine.medical_specialty Adolescent Genotype Tryptase Pathology and Forensic Medicine Chymases Bacterial Proteins Internal medicine Gastrins medicine Gastric mucosa CagA Humans Dyspepsia Aged Analysis of Variance Antigens Bacterial Helicobacter pylori biology.organism_classification bacterial infections and mycoses digestive system diseases Enzyme Activation chemistry Gastric Mucosa Duodenal Ulcer Immunology biology.protein Tryptases |
| Zdroj: | Journal of clinical pathology. 52(3) |
| ISSN: | 0021-9746 |
| Popis: | AIMS: To determine the association, if any, between H pylori genotype and the gastric mucosal variations in the levels of gastrin, somatostatin, tryptase, and histamine. METHODS: 49 patients affected by duodenal ulcer and 48 by non-ulcer dyspepsia were studied. To identify the H pylori genotype, the presence of the cagA gene and vacA alleles m1, m2, s1, and s2 were analysed by polymerase chain reaction. Gastrin, somatostatin, tryptase, and histamine were measured in antral mucosal biopsies. RESULTS: 57 patients were infected with H pylori (30 with duodenal ulcer and 27 with non-ulcer dyspepsia). Gastrin and tryptase were increased in patients with H pylori infection, although the variations were statistically significant only for gastrin; somatostatin and histamine were not influenced by H pylori infection. In patients with non-ulcer dyspepsia the absence of the cagA gene and the presence of vacA alleles s2 and m2 were associated with higher values of tryptase and to a lesser extent of gastrin. These associations were not found in patients with duodenal ulcer. CONCLUSIONS: The cagA negative s2m2 strain of H pylori may be less dangerous for the gastric mucosa than other H pylori strains since it enhances tryptase production by gastric mucosal mast cells; this enzyme is thought to stimulate tissue turnover and favour wound healing. |
| Databáze: | OpenAIRE |
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