A dissection of SARS-CoV2 with clinical implications (Review)
| Autor: | Georgios Z. Papadakis, B. Izotov, Stelios Kteniadakis, Michael D. Coleman, Aristidis Tsatsakis, Demetrios A. Spandidos, Felician Stancioiu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty ARDS Simvastatin Curcumin Psychological intervention antiviral treatment coronavirus Amiodarone arginine sepsis 03 medical and health sciences 0302 clinical medicine Pandemic Genetics medicine Sore throat Animals Humans Intensive care medicine Respiratory Distress Syndrome Pioglitazone business.industry SARS-CoV-2 COVID-19 General Medicine Articles ascorbate medicine.disease Dissection 030104 developmental biology 030220 oncology & carcinogenesis SARS-CoV2 medicine.symptom business medicine.drug |
| Zdroj: | International Journal of Molecular Medicine |
| ISSN: | 1791-244X 1107-3756 |
| Popis: | We are being confronted with the most consequential pandemic since the Spanish flu of 1918‑1920 to the extent that never before have 4 billion people quarantined simultaneously; to address this global challenge we bring to the forefront the options for medical treatment and summarize SARS‑CoV2 structure and functions, immune responses and known treatments. Based on literature and our own experience we propose new interventions, including the use of amiodarone, simvastatin, pioglitazone and curcumin. In mild infections (sore throat, cough) we advocate prompt local treatment for the naso‑pharynx (inhalations; aerosols; nebulizers); for moderate to severe infections we propose a tried‑and‑true treatment: the combination of arginine and ascorbate, administered orally or intravenously. The material is organized in three sections: i) Clinical aspects of COVID‑19; acute respiratory distress syndrome (ARDS); known treatments; ii) Structure and functions of SARS‑CoV2 and proposed antiviral drugs; iii) The combination of arginine‑ascorbate. |
| Databáze: | OpenAIRE |
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