Epidemiological Characteristics and Clinical Features of Patients Infected With the COVID-19 Virus in Nanchang, Jiangxi, China
| Autor: | Yanhui Chen, Qiaoshi Zhong, Yaping Hang, Jianping Xu, Longhua Hu, Long-Chuan Zhu, Jian-Ming Hong, Hua-Bao Sun, Zhi-Hua Huang, Xueyao Fang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Lymphocyte Physical examination Disease 030204 cardiovascular system & hematology Chronic liver disease Asymptomatic Virus close contact 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology Pandemic medicine asymptomatic 030212 general & internal medicine Original Research biochemical & physiological biomarkers lcsh:R5-920 medicine.diagnostic_test business.industry COVID-19 General Medicine medicine.disease cytokines medicine.anatomical_structure epidemiogy Medicine medicine.symptom business lcsh:Medicine (General) |
| Zdroj: | Frontiers in Medicine, Vol 7 (2020) Frontiers in Medicine |
| DOI: | 10.3389/fmed.2020.571069/full |
| Popis: | Objectives: The 2019 novel coronavirus disease (COVID-19) pandemic is the biggest public health crises in the 21st century. While most patients infected with the COVID-19 virus have no to moderate symptoms, there is currently limited clinical information about these patients. Methods: In this study, we retrospectively investigated 41 patients infected with the COVID-19 virus in Nanchang, Jiangxi province, China, from February 4 to March 2, 2020. Nanchang is about 260 km southeast of Wuhan, the initial epicenter of the COVID-19 pandemic. We retrieved information on patient demographics, physical examination results, epidemiology, clinical manifestations, underlying conditions, laboratory analyses, radiological images, and treatment outcomes. Results: Most patients (70.7%) had a history of close contact with patients with confirmed COVID-19, and 16 patients (39.0%) showed a high degree of family clustering. All 41 patients had no to moderate symptoms. The median age was 39.9 years and common symptoms of illness were fever (69.2%), cough (65.4%), and fatigue (19.2%). The dominant patient group was middle-aged women, with hypertension (14.6%) and chronic liver disease (12.2%) as the most frequent underlying conditions. All patients recovered, with the mean time of viral nucleic acid clearance at 10.6 days. Chest CT scans presented ground-glass opacities in 53.7% of patients while 26.8% had normal CT images. Laboratory results showed that lymphocyte counts, lymphocyte percentages, ESR, CRP, IgG, Fib, and cytokines were correlated to patients' conditions. Approximately 60-90% of patients had abnormally high levels of cytokines IL-4, IL-6, IL-10, and/or TNF-α. Conclusions: Our results showed variable clinical and laboratory presentations among this group of patients infected with the COVID-19 virus. Though all 41 patients recovered, our results suggest that cytokine levels and other biochemical indicators should be monitored for patients infected with the COVID-19 virus showing no to moderate symptoms to ensure quick access for critical medical attention, if needed. |
| Databáze: | OpenAIRE |
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