Positive Selection of Vβ2+ CD8+ T cells
| Autor: | Kyuhei Tomonari |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Receptors
Antigen T-Cell alpha-beta Immunology Mice Inbred Strains Cell Separation Thymus Gland Biology Gene Rearrangement T-Lymphocyte Mice Inbred strain T-Lymphocyte Subsets MHC class I Superantigen Animals Immunology and Allergy Cytotoxic T cell Selection Genetic Beta (finance) Crosses Genetic Genetics T-cell receptor H-2 Antigens Cell Differentiation General Medicine T lymphocyte Flow Cytometry Molecular biology biology.protein CD8 |
| Zdroj: | International Immunology. 4:1195-1198 |
| ISSN: | 1460-2377 0953-8178 |
| DOI: | 10.1093/intimm/4.10.1195 |
| Popis: | T cells bearing V beta 4, V beta 6, V beta 10, V beta 14, and V beta 17a are positively selected by MHC class I and/or class II molecules with poorly elucidated mechanisms. In this paper levels of V beta 2+ CD4+ and V beta 2+ CD8+ T cells from 33 inbred, five F1 hybrid, and 48 [(C58 x DBA/2)F1 x DBA/2] backcross mice have been examined. The results show that (i) V beta 2+ CD8+ T cells are positively selected by MHC class I H-2k molecules, (ii) this positive selection might be mediated by a non-H-2 ligand(s) in association with the Kk molecule, and (iii) inbred strains of mice, so far examined, do not have endogenous superantigens for deletion of V beta 2+ T cells. |
| Databáze: | OpenAIRE |
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