| Autor: |
Chuanming Xu, Yanting Chen, Nirupama Ramkumar, Chang‐Jiang Zou, Curt D. Sigmund, Tianxin Yang |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Acta physiologica (Oxford, England)REFERENCES. 237(1) |
| ISSN: |
1748-1716 |
| Popis: |
The kaliuretic action of the renin-angiotensin-aldosterone system (RAAS) is well established as highlighted by hyperkalemia side effect of RAAS inhibitors but such action is usually ascribed to systemic RAAS. The present study addresses the involvement of intrarenal RAAS in KWild-type (Floxed) and CD-specific deletion of renin (CD renin KO) mice were treated for 7 days with a high KIn floxed mice, renin levels were elevated in the renal medulla and urine following a 1-week HK diet, indicating activation of the intrarenal renin. CD renin KO mice had blunted HK-induced intrarenal renin response and developed impaired kaliuresis and elevated plasma KTaken together, these results support a kaliuretic action of CD renin during HK intake. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text