A clinical case of diagnosis of breast cancer in patients with family history of BRCA mutations 1
| Autor: | Yerbol Bekmukhambetov, Gaziza A. Smagulova, Oksana Zavalyonnaya, Marzhan A. Aitmagambetova, Anar Tulyaeva |
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| Rok vydání: | 2021 |
| Předmět: |
Daughter
Pediatrics medicine.medical_specialty heredity business.industry media_common.quotation_subject Incidence (epidemiology) BRCA mutation Disease medicine.disease breast cancer Breast cancer Oncology Carcinoma medicine Genetic predisposition case report Radiology Nuclear Medicine and imaging Family history skin and connective tissue diseases business media_common |
| Zdroj: | Reports of Practical Oncology and Radiotherapy |
| ISSN: | 2083-4640 1507-1367 |
| DOI: | 10.5603/rpor.a2021.0069 |
| Popis: | BACKGROUND: The incidence of breast cancer is growing rapidly worldwide (1.7 million new cases and 600,000 deaths per year). Moreover, about 10% of breast cancer cases occur in young women under the age of 45. The aim of the study was to report a rare case of BRCA1-mutated breast cancer in a young patient with multiple affected relatives. CASE PRESENTATION: Breast cancer is due to a genetic predisposition with BRCA1 and BRCA2 representing a significant proportion of families with a very high risk of developing the disease over a lifetime of up to 50–80%. In this paper we report a case of a 29-year-old woman with a confirmed diagnosis of left breast carcinoma. CONCLUSIONS: Mutations of the BRCA1 gene were revealed in the patient, in two of her sisters, brother and brother’s daughter. |
| Databáze: | OpenAIRE |
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