Performance evaluation of the PET component of a sequential APD-based micro-PET/MR imaging system
| Autor: | P Walker, B Barbier, F. Brunotte, B. Collin, A Camacho, Alexandra Oudot, J.M. Vrigneaud |
|---|---|
| Přispěvatelé: | Service de Médecine Nucléaire, Centre Georges-François Leclerc [Dijon] (CGFL), Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Trifoil Imaging, MR Solutions Guildford, Service de Médecine Nucléaire, Centre Georges-François Leclerc [Dijon] ( CGFL ), Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Laboratoire Electronique, Informatique et Image ( Le2i ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Arts et Métiers (ENSAM), HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
PET/MR imaging
Materials science [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging 010308 nuclear & particles physics small-animal preclinical PET 01 natural sciences Mr imaging 030218 nuclear medicine & medical imaging performance evaluation 03 medical and health sciences 0302 clinical medicine 13. Climate action Component (UML) 0103 physical sciences [INFO.INFO-IM]Computer Science [cs]/Medical Imaging APD d etectors Micro pet General Nursing Biomedical engineering |
| Zdroj: | Biomedical Physics & Engineering Express Biomedical Physics & Engineering Express, IOP Publishing, 2017, ⟨10.1088/2057-1976/aa686d⟩ Biomedical Physics & Engineering Express, 2017, 〈http://iopscience.iop.org/article/10.1088/2057-1976/aa686d〉. 〈10.1088/2057-1976/aa686d〉 |
| ISSN: | 2057-1976 |
| DOI: | 10.1088/2057-1976/aa686d⟩ |
| Popis: | International audience; The LabPET/MR imaging system is a new preclinical prototype with sequentially-acquired PET/MR scan capabilities. The dual modality system is composed of a modified APD-based LabPET4 subsystem, coupled with a cryogen-free superconducting 3.0T MRI subsystem. The objective of the study was to characterize the imaging performance of the PET subsystem and identify the change in PET performance due to the presence of the magnetic field. NEMA NU-4-2008 performance characteristics were conducted with the MR subsystem switched ON and OFF. Influence of the temperature was also investigated by repeating selected performance tests. In the ON configuration, the radial/tangential FBP spatial resolution ranged from 1.62 ± 0.08 /1.88 ± 0.08 mm to 2.83 ± 0.11/2.03 ± 0.03 mm at the axial center field of view. The peak absolute sensitivity for an energy window of 250-650 keV was 0.87%. The maximum noise equivalent counting rates were 133 kcps at 3.8 MBq/mL and 25 kcps at 0.4 MBq/mL for the mouse- and rat- like phantoms, respectively. The corresponding scatter fractions were 13% and 23%. No differences could be identified between the ON and OFF configuration, except for a mean loss in peak absolute sensitivity of 5.1 ± 0.5% which was attributed to a mean rise in temperature of 1.2°C when the magnet was ON. Compared with the LabPET standalone scanner, the LabPET/MR imaging prototype is working in a warmer environment and this impacts on the sensitivity of the APD-based LabPET scanner. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|