eFigure 3 from Amphiregulin Expression Is a Predictive Biomarker for EGFR Inhibition in Metastatic Colorectal Cancer: Combined Analysis of Three Randomized Trials

Autor: Volker Heinemann, Andreas Jung, Thomas Kirchner, Jens Neumann, Markus Moehler, Thomas Decker, Swantje Held, Alexander Kiani, Martina Stauch, Andreas Schalhorn, Nicolas Moosmann, Ludwig Fischer von Weikersthal, Florian Kaiser, Boryana Ivanova, Christine Kapaun, Clemens Giessen-Jung, Ingrid Ricard, Dominik P. Modest, Sebastian Stintzing, Arndt Stahler
Rok vydání: 2023
DOI: 10.1158/1078-0432.22476944.v1
Popis: Median AREG (A) and EGFR (B) expression and their 95% confidence interval (95% CI, grey shaded). Median AREG expression was lower in right- compared to left-sided primary tumor locations, while only tumors located in caecum, ascending colon, hepatic flexure and descending colon showed low EGFR expression. The red dashed lines mark the pre-specified threshold values 0.5 for AREG and 22.5 for EGFR expression.
Databáze: OpenAIRE