Evaluation of Biochemical Parameters Present in the Saliva of Patients with Chronic Periodontitis: Results from a Meta-Analysis
| Autor: | Luiz Felipe de Carvalho França, Daniel Fernando Pereira Vasconcelos, David Di Lenardo, Joaquina dos Santos Carvalho, Felipe Rodolfo Pereira da Silva, Even Herlany Pereira Alves |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Saliva Pathology medicine.medical_specialty Acid Phosphatase 03 medical and health sciences 0302 clinical medicine stomatognathic system Tissue degradation medicine Humans Gingival sulcus Aspartate Aminotransferases Creatine Kinase Genetics (clinical) Dental alveolus Periodontitis L-Lactate Dehydrogenase business.industry Alanine Transaminase General Medicine medicine.disease Alkaline Phosphatase Chronic periodontitis Resorption 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis Case-Control Studies Chronic Periodontitis Female business |
| Zdroj: | Genetic testing and molecular biomarkers. 23(4) |
| ISSN: | 1945-0257 |
| Popis: | Periodontitis results from the presence of periodontopathogenic bacterial activity in the region of the gingival sulcus promoting tissue degradation and alveolar bone resorption. Biochemical analysis of the saliva can be used as a less invasive method for disease prognosis. This study aimed to evaluate the relationship between biochemical protein levels in the saliva sample of patients with chronic periodontitis and healthy patients.A literature review was performed using electronic databases (Cochrane Library, Google Scholar, MEDLINE, PubMed, and Web of Science) for studies published before July 2, 2016. The abstracts were evaluated, and the data extraction was performed by two calibrated examiners. The mean difference, and heterogeneity were calculated, and funnel plots were produced.Twenty case-control studies were selected with 2436 patients with chronic periodontitis and 1787 controls. The meta-analysis showed that increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and acid phosphatase (ACP) were all associated with periodontitis (p 0.05), while blood urea nitrogen (BUN) and osteoprotegerin (OPG) levels did not show statistical differences between cases and controls (p 0.05).This meta-analysis evidenced that increased levels of AST, ALT, CK, gama glutamil transferase (GGT), LDH, ALP, and ACP are associated in patients with chronic periodontitis, while BUN and OPG level in saliva did not present differences between groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|