Visceral adipose tissue in patients with COVID-19: risk stratification for severity
| Autor: | Henry Rusinek, Myles T. Taffel, Artem Mikheev, Bari Dane, Yang Feng, Hersh Chandarana |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Coronavirus disease 2019 (COVID-19) medicine.medical_treatment Urology Adipose tissue Intra-Abdominal Fat Risk Assessment Severity of Illness Index 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult 0302 clinical medicine Disease severity Internal medicine medicine Humans Radiology Nuclear Medicine and imaging In patient Aged Retrospective Studies Mechanical ventilation Aged 80 and over Radiological and Ultrasound Technology business.industry SARS-CoV-2 Visceral adipose tissue (VAT) Area under the curve Gastroenterology COVID-19 Middle Aged Radiology Nuclear Medicine and imaging 030220 oncology & carcinogenesis Risk stratification Female Peritoneum business Tomography X-Ray Computed Body mass index CT |
| Zdroj: | Abdominal Radiology (New York) Abdominal Radiology |
| ISSN: | 2366-0058 |
| Popis: | Purpose To assess visceral (VAT), subcutaneous (SAT), and total adipose tissue (TAT) estimates at abdominopelvic CT in COVID-19 patients with different severity, and analyze Body Mass Index (BMI) and CT estimates of fat content in patients requiring hospitalization. Methods In this retrospective IRB approved HIPPA compliant study, 51 patients with SARS-CoV-2 infection with abdominopelvic CT were included. Patients were stratified based on disease severity as outpatient (no hospital admission) and patients who were hospitalized. Subset of hospitalized patient required mechanical ventilation (MV). A radiologist blinded to the clinical outcome evaluated single axial slice on CT at L3 vertebral body for VATL3, SATL3, TATL3, and VAT/TATL3. These measures along with age, gender, and BMI were compared. A clinical model that included age, sex, and BMI was compared to clinical + CT model that also included VATL3 to discriminate hospitalized patients from outpatients. Results There were ten outpatients and 41 hospitalized patients. 11 hospitalized patients required MV. There were no significant differences in age and BMI between the hospitalized and outpatients (all p > 0.05). There was significantly higher VATL3 and VAT/TATL3 in hospitalized patients compared to the outpatients (all p |
| Databáze: | OpenAIRE |
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