Elevated serum S100B protein and neuron-specific enolase levels in carbon monoxide poisoning
| Autor: | Yücel Yüzbaşıoğlu, Omer Donderici, Gulsen Yilmaz, Yunsur Çevik, Yahya Kemal Gunaydin, Türker Yardan, Fatma Meric Yilmaz, Cemil Kavalci, Ahmet Ali Sezer, Kubilay Vural |
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| Přispěvatelé: | Ondokuz Mayıs Üniversitesi |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Resuscitation Enolase S100 Calcium Binding Protein beta Subunit Gastroenterology Elevated serum Carbon Monoxide Poisoning Young Adult Internal medicine Intensive care medicine Humans Nerve Growth Factors Prospective Studies Young adult Prospective cohort study Hypoxia Brain business.industry Carbon monoxide poisoning S100 Proteins General Medicine Hypoxia (medical) Middle Aged medicine.disease nervous system Anesthesia Phosphopyruvate Hydratase Emergency Medicine Female medicine.symptom business Biomarkers |
| Zdroj: | The American journal of emergency medicine. 27(7) |
| ISSN: | 1532-8171 |
| Popis: | Yilmaz, Gulsen/0000-0002-9630-3852 WOS: 000269311400014 PubMed: 19683113 Objective: Carbon monoxide (CO) poisoning causes cerebral and generalized hypoxia. This study aimed to assess the possible use of serum glial marker S 10013 protein and neuron-specific enolase (NSE) as biochemical markers of hypoxic brain damage in acute CO poisoning. Methods: Patients with acute CO poisoning admitted to the ED of 2 training hospitals (Ankara, Turkey) were included in this cross-sectional study. Serum levels of S100B and NSE were measured on admission. The patients were divided into 2 groups (unconscious and conscious). Twenty healthy adults were included in the study to serve as controls. Results: A total of 70 patients poisoned by CO (mean age +/- SD, 36.6 +/- 16.3 years; 64.3% women) were enrolled. Although S100B concentrations were higher in patients than in the control group (P=.018), no significant difference was determined between patient and control groups with respect to NSE concentrations (P=.801). A positive correlation was noted between levels of S100B and NSE (r=0.388; P=.001). The S 10013 and NSE values were higher in unconscious patients than in the control group (P.002 and P=.013, respectively). Furthermore, S100B and NSE values were higher in unconscious vs unconscious patients (P=.047 and P=.005, respectively). Conclusion: Elevated serum S100B and NSE levels were associated with loss of consciousness in CO poisoning in this series of patients. Serum S100B and NSE may be useful markers in the assessment of clinical status in CO poisoning. (C) 2009 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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