Evaluation of treatment with pentamidine for cutaneous leishmaniasis in Suriname
| Autor: | Wendy F. van der Meide, Rudy F. M. Lai A. Fat, Annigje J. Jensema, Inge Peekel, Leslie O. A. Sabajo, Henk D. F. H. Schallig, W.R. Faber |
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| Přispěvatelé: | Dermatology, KIT: Biomedical Research, Medical Microbiology and Infection Prevention |
| Rok vydání: | 2009 |
| Předmět: |
Drug
Adult Male medicine.medical_specialty Pentamidine Isethionate Adolescent Endemic Diseases media_common.quotation_subject Leishmaniasis Cutaneous Dermatology Injections Intramuscular Polymerase Chain Reaction Risk Assessment Severity of Illness Index Drug Administration Schedule Statistics Nonparametric Cohort Studies Young Adult Pharmacotherapy Cutaneous leishmaniasis Internal medicine medicine Animals Humans Patient compliance Developing Countries Pentamidine media_common Probability Leishmania Suriname biology Dose-Response Relationship Drug business.industry Leishmaniasis Middle Aged biology.organism_classification medicine.disease Surgery Treatment Outcome Patient Compliance Female business Polymorphism Restriction Fragment Length medicine.drug Follow-Up Studies |
| Zdroj: | International journal of dermatology, 48(1), 52-58. Wiley-Blackwell |
| ISSN: | 1365-4632 0011-9059 |
| Popis: | Background In Suriname, pentamidine isethionate (PI) is the only drug available for the treatment of cutaneous leishmaniasis (CL). Recently, local dermatologists have observed an increase in CL patients not responding adequately to the standard doses. Methods In this study, patient compliance to PI treatment was assessed, and its efficacy was evaluated by comparing the clinical criteria and parasitologic load in week 3 of treatment. Skin biopsies were collected before, during and at the end of therapy and tested by quantitative nucleic acid sequence-based amplification. Results In total, 67 patients with suspected CL were enrolled during the recruitment period, of which only 23 patients with confirmed CL were followed until the end of treatment. All 23 patients were found to be infected with Leishmania (Viannia) guyanensis. A lower cure rate (76–78%) was estimated than that obtained previously (90%), and only 50% of the recruited CL patients finished the complete treatment schedule. Conclusions As one-half of the CL patients were treated insufficiently, a much shorter treatment protocol should be considered to improve the inadequate follow-up. |
| Databáze: | OpenAIRE |
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