Role of viral chromatin structure in the regulation of herpes simplex virus 1 gene expression and replication
| Autor: | John A. Blaho, Kristin Ingvarsdottir |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
Gene Expression Regulation Viral biology Herpesvirus 1 Human medicine.disease_cause Virus Replication Microbiology Virology Chromatin remodeling Chromatin Herpes simplex virus Histone Gene expression Histone H2A DNA Viral medicine biology.protein Histone code Humans Lytic Phase |
| Zdroj: | Future microbiology. 4(6) |
| ISSN: | 1746-0921 |
| Popis: | Herpes simplex virus 1 initially infects epithelial cells during the lytic phase of its infectious cycle, followed by establishment of the latent phase within neuronal cells. The two different phases of infection are characterized by distinct gene-expression profiles, involving a temporal gene-expression pattern during the lytic phase succeeded by a complete shutdown of all gene expression, except for one abundant transcript, during the latent phase. The mechanisms controlling these varying degrees of gene expression appear to involve regulation of the viral chromatin structure, presumably using many of the same tactics employed by the host cell. |
| Databáze: | OpenAIRE |
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