Clinicopathological correlates of Alzheimer's disease in a general autopsy series from Brazil
| Autor: | Heidy T.M. Matos, Wilson Jacob-Filho, Katia C. Oliveira, Paulo Hilário Nascimento Saldiva, Ricardo Nitrini, E. S Balbino, Renata Patricia Soares Grisoli, E. G Moreira, Carlos Augusto Pasquallucci, Renata E.L. Ferretti, José Marcelo Farfel, Sérgio Rosemberg, Ana Teresa Di Lorenzo Alho, Heráclito Barbosa Carvalho, Lea T. Grinberg, Renata Elaine Paraizo Leite, Silmara P. Pacheco |
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| Rok vydání: | 2007 |
| Předmět: |
Gerontology
critérios diagnósticos medicine.medical_specialty doença de Alzheimer Clinical Dementia Rating Cognitive Neuroscience Score Disease banco de encéfalos lcsh:RC321-571 Internal medicine mental disorders brain bank medicine Dementia Aging brain Stage (cooking) lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry demência critérios neuropatológicos Original Articles Alzheimer's disease medicine.disease banco de cérebros Sensory Systems Autopsy series neuropathological criteria Neurology diagnostic criteria Brain bank Neurology (clinical) Geriatrics and Gerontology Psychology Alzheimer’s disease dementia |
| Zdroj: | Dementia & Neuropsychologia, Volume: 1, Issue: 4, Pages: 356-360, Published: DEC 2007 Dementia & Neuropsychologia v.1 n.4 2007 Dementia & Neuropsychologia Associação de Neurologia Cognitiva e do Comportamento (ANCC) instacron:ANCC Dementia & Neuropsychologia, Vol 1, Iss 4, Pp 356-360 |
| ISSN: | 1980-5764 |
| DOI: | 10.1590/s1980-57642008dn10400005 |
| Popis: | The current neuropathological staging models of Alzheimer's disease (AD) have been developed within the last 20 years. Nevertheless, they were mostly tested on Caucasians of Northern European ancestry or on Asians. Objective: To verify which of the accepted neuropathologic criteria best discriminates AD from normal aging in a well characterized Brazilian clinicopathological series. Methods: A random sample consisting of 89 subjects belonging to the Brazilian Brain Bank of the Aging Brain Study were clinically and neuropathologically fully assessed using immunohistochemistry. Clinical and functional statuses were assessed by interviewing a reliable informant. The Clinical dementia rating scale (CDR) was compared to Braak and Braak stage, the consortium to establish a registry for Alzheimer's disease (CERAD) score and NIA-Reagan (National Institute of Aging - Reagan Institute) score. Subjects with a neuropathologic diagnosis other then AD were excluded (n=27). Results: The CDR score distribution for the 62 selected subjects was as follows: CDR0=39, CDR0.5=9, CDR³1=14. There were no differences regarding age, gender and education among the groups. CDR score correlated best with the CERAD score (r=0.5303; p |
| Databáze: | OpenAIRE |
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