Potential Role of Selenium Against Hepatotoxicity Induced by 2,4-Dichlorophenoxyacetic Acid in Albino Wistar Rats
| Autor: | Lazhari Tichati, Fouzia Trea, Kheireddine Ouali |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry chemistry.chemical_element Administration Oral 010501 environmental sciences 01 natural sciences Biochemistry Antioxidants Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound Selenium Lactate dehydrogenase Internal medicine medicine Animals Rats Wistar 0105 earth and related environmental sciences chemistry.chemical_classification 0303 health sciences Glutathione Peroxidase Molecular Structure Glutathione peroxidase 030302 biochemistry & molecular biology Biochemistry (medical) General Medicine Glutathione Malondialdehyde Rats Endocrinology chemistry Liver Toxicity Dietary Supplements Alkaline phosphatase Liver function 2 4-Dichlorophenoxyacetic Acid |
| Zdroj: | Biological trace element research. 194(1) |
| ISSN: | 1559-0720 |
| Popis: | The present study aims to investigate the hepatoprotective effects of selenium on toxicity induced by ‘Desormone Lourd’ based on 2,4-dichlorophenoxyacetic acid in Wistar rats. Male Wistar rats were divided into four groups and were treated orally. The (C) group was used as a control, while the test groups were treated with Se (0.2 mg/kg b.w.), 2,4-D (5 mg/kg b.w.) or both (2,4-D + Se) for 4 weeks. Our results showed that chronic treatment with 2,4-D resulted in hepatotoxicity, as revealed by an increase in liver function markers Aminotransferases (ALT, AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and total bilirubin (TB), along with reduced total protein content and albumin. An overall pro-oxidant effect was associated with a decrease in the reduced glutathione (GSH) content and the enzymatic activity of glutathione-S-transferase (GST), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx), and an increase in malondialdehyde (MDA) and protein carbonyl levels (PCO). Microscopic observation of liver in 2,4-D-treated rats reveals lesions, which results in perivascular inflammatory infiltration around the vessel, sinusoidal dilatation and vacuolization of hepatocytes. However, selenium supplementation in 2,4-D-treated rats elicited a reduction in the toxic effects of the pesticide by improving the studied parameters, which was confirmed by the histological study of the liver. Selenium appears to have a promising prophylactic effect through its effective anti-radical action against the hepatotoxic effects of 2,4-D. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink