Lipid Deposition in Various Sites of the Skeletal Muscles and Liver Exhibits a Positive Correlation with Visceral Fat Accumulation in Middle-aged Japanese Men with Metabolic Syndrome
| Autor: | Shin-ichiro Taira, Takako Iha, Sawako Nakachi, Michio Shimabukuro, Hiroaki Masuzaki, Kouichi Yabiku, Mototsugu Doi, Yoshiro Nakayama, Sumito Sunagawa, Toyotaka Nanba, Yuzuru Ohshiro, Tomomi Ikema, Hideaki Nakamura, Moritake Higa, Ken Yamakawa, Rei Ueda, Chisayo Kozuka, Takeaki Tomoyose, Eriko Kawamoto |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Iliopsoas Muscle Type 2 diabetes Intra-Abdominal Fat Diabetes mellitus Internal medicine Internal Medicine medicine Humans Hypoglycemic Agents Muscle Skeletal Aged Metabolic Syndrome business.industry Miglitol Skeletal muscle General Medicine Middle Aged Lipid Metabolism medicine.disease Pathophysiology Fatty Liver medicine.anatomical_structure Endocrinology Metabolic syndrome Tomography X-Ray Computed business Risk Reduction Behavior Pioglitazone medicine.drug |
| Zdroj: | Internal Medicine. 52:1561-1571 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.52.0521 |
| Popis: | Objective In addition to excess visceral fat, lipid deposition in the liver and skeletal muscle has been implicated in the pathophysiology of type 2 diabetes and metabolic syndrome. This study was designed to explore the relationship between hepatic and muscular lipid deposition and visceral fat accumulation in 105 middle-aged men with metabolic syndrome. Methods Abdominal computed tomography (CT) was used to simultaneously evaluate the visceral fat area (VFA) and CT Hounsfield unit (HU) values of three different portions of skeletal muscle and the liver. Results A significant inverse correlation was observed between the VFA and the CT HU values of the iliopsoas muscle, back muscle, rectus abdominis muscle and liver. Three types of interventions, i.e., lifestyle modification and treatment with antidiabetic drugs, such as Pioglitazone or Miglitol, caused significant decreases in visceral fat accumulation. The extent of lipid deposition in the liver was strongly correlated with the levels of glucose-lipid metabolic markers, which decreased significantly following Pioglitazone treatment. On the other hand, the amount of lipid deposition in the three skeletal muscles and the liver did not decrease after Miglitol treatment. Conclusion Visceral fat accumulation is accompanied by excess lipid deposition in skeletal muscle and the liver in patients with metabolic syndrome. The CT-based simultaneous, concise evaluations of ectopic lipid deposition and visceral fat mass used in the present study may provide unique information for assessing cardiometabolic risks and the therapeutic impact in patients with diabetes-obesity syndrome. |
| Databáze: | OpenAIRE |
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