Evaluation of somatic cell variants deficient in glycosylphosphatidyl-inositol anchoring as candidates for genetic correction
| Autor: | Claude Bron, Marga Rousseaux, C. Beghdadi-Rais, Michel Bernard, Nicole Déglon, Nicolas Fasel |
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| Rok vydání: | 1991 |
| Předmět: |
Membrane Glycoproteins
Glycosylphosphatidylinositols Somatic cell Cell Anchoring Cell Biology Biology Phosphatidylinositols Transfection Cell Line chemistry.chemical_compound medicine.anatomical_structure Biochemistry Biosynthesis chemistry Cell culture Tumor Cells Cultured medicine Animals Humans lipids (amino acids peptides and proteins) Glycolipids Lipid bilayer Fibroblast Gene |
| Zdroj: | Cell Biology International Reports. 15:1051-1064 |
| ISSN: | 0309-1651 |
| Popis: | Many cell surface glycoproteins are anchored in the lipid bilayer by a glycosylphosphatidyl-inositol (GPI) structure. Recently, a number of cell lines which are deficient in the biosynthesis and/or addition of this anchor have been described. In this report, we summarize the current knowledge on these lines and discuss their potential use to isolate the genes involved in the GPI anchor biosynthetic pathway with a specific emphasis on L cell fibroblasts. |
| Databáze: | OpenAIRE |
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