Plasma endoglin in Type2 diabetic patients with nephropathy
| Autor: | Rania Y. Zakaria, Atef A. Bassyouni, Ahmed S. Doghish, Heba G. Abd El-Aziz, Mohamed H. Mahfouz |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Renal function 030204 cardiovascular system & hematology Nephropathy Diabetic nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus Internal Medicine medicine Humans Diabetic Nephropathies Creatinine business.industry Endoglin General Medicine Middle Aged medicine.disease 030104 developmental biology Endocrinology chemistry Diabetes Mellitus Type 2 Albuminuria Microalbuminuria Female medicine.symptom business Biomarkers |
| Zdroj: | Diabetesmetabolic syndrome. 13(1) |
| ISSN: | 1878-0334 |
| Popis: | Background Diabetic nephropathy may be a common complication of diabetes mellitus. Endoglin is glycoprotein located on cell surfaces of endothelial cells and is part of the transforming growth factor beta (TGF- β) receptor. Endoglin expression is enhanced in endothelial cells during injury and inflammation. The aim of this study was to estimate the plasma level of soluble endoglin (sEng) in type 2 diabetic patients (with and without nephropathy). Also to explore its availability as marker for disease progression. Methods In this study, sixty eight patients with type 2 diabetes mellitus (T2DM) were included; the patients were sub-grouped to normoalbuminuria without nephropathy and moderately increased albuminuria (microalbuminuria) with nephropathy groups with 13 individuals as control group. Plasma soluble endoglin level was determined using ELISA technique. Fasting plasma glucose (FPG), glycated haemoglobin (HbA1c), lipid profile, and creatinine were determined using colorimetric assay, whereas glomerular filtration rate (GFR) was calculated. Results The plasma level of sEng of both normoalbuminuria group 1 and microalbuminuria group 2 were significantly higher when compared to control group. While, the plasma level of sEng in microalbuminuria group 2 was nonsignificant lower when compared to normoalbuminuria group 1. Also, there was a significant positive association between plasma level of sEng and HbA1c, HDL-C and urinary albumin concentration in normoalbuminuria group. Conclusion Plasma level of soluble Endoglin is markedly increase prior to alteration in endothelial function, and increases to lesser extent with the developing of diabetic nephropathy which indicated disease progression and development of vascular abnormalities. |
| Databáze: | OpenAIRE |
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