Increased fetal heart rate variability in periventricular leukomalacia
| Autor: | Atsuo Itakura, Akihisa Okumura, Kazuyoshi Watanabe, Masahiro Hayakawa, Tetsuo Kubota, Koichi Maruyama, Hirokazu Kurahashi, Hiroyuki Kidokoro, Toru Kato, Fumio Hayakawa, Hiroyuki Yamamoto, Katsuji Matsuzawa |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Fetal Heart Rate Variability Leukomalacia Periventricular Gestational Age 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Pregnancy Risk Factors 030225 pediatrics Internal medicine Heart rate Humans Medicine Fetus Periventricular leukomalacia business.industry Infant Newborn Area under the curve Infant Gestational age General Medicine Heart Rate Fetal bacterial infections and mycoses medicine.disease Pediatrics Perinatology and Child Health Cardiology Gestation Female Neurology (clinical) business Premature rupture of membranes Infant Premature 030217 neurology & neurosurgery |
| Zdroj: | Brain and Development. 38:196-203 |
| ISSN: | 0387-7604 |
| Popis: | Objective This study used quantitative analysis to determine whether increased variability in fetal heart rate (FHR) is related to the risk of developing periventricular leukomalacia (PVL). Methods We analyzed 124 FHR traces of neonates delivered preterm at 27–33 weeks’ gestation to 105 mothers. FHR traces 1–3 h before delivery were translated into power-spectrum curves using a fast Fourier transformation. The total power (the area under the curve of 1–10 cycles per minute), segmental power of every cycle per minute, peak power, and frequency edges were calculated, and their relationship with the subsequent development of PVL was examined. Results Total power was significantly higher in the PVL group (n = 9, median 1813, range 1064–2426) compared to the non-PVL group (n = 114, median 1383, range 381–3324, p = 0.029). Infants in the PVL group had greater segmental power in segments with 1–2, 2–3, and 9–10 cycles per minute, than those in the non-PVL group. Total power of ⩾1550 was significantly correlated with the subsequent development of PVL and premature rupture of membranes. Furthermore, the frequency of pregnancy-induced hypertension was significantly reduced in the fetuses with a total power of ⩾1550. Conclusion Our study suggests that a fetus with increased FHR variability is at risk of developing PVL. This study provides additional evidence supporting the contribution of antenatal factors to the subsequent development of PVL. |
| Databáze: | OpenAIRE |
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