Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae
| Autor: | Thomas Efferth, Eman G. Haggag, Hisashi Matsuda, Paul W. Paré, Faiza Hammouda, Mahmoud A. A. Ibrahim, Ahmed R. Hamed, Seikou Nakamura, Eman H. Reda, Mohamed-Elamir F. Hegazy, Nahla S. Abdel-Azim, Zienab Talat |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pharmaceutical Science
Tumor cells 01 natural sciences Analytical Chemistry TDDTF-ECD lcsh:QD241-441 tumor anti-proliferative activity lcsh:Organic chemistry Drug Discovery Physical and Theoretical Chemistry Solvent extraction A549 cell Euphorbia biology Traditional medicine 010405 organic chemistry Chemistry Organic Chemistry Euphorbiaceae diterpenes Euphorbia sanctae-catharinae biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Chemistry (miscellaneous) flavonoids Molecular Medicine |
| Zdroj: | Molecules, Vol 23, Iss 9, p 2221 (2018) Molecules Volume 23 Issue 9 |
| ISSN: | 1420-3049 |
| Popis: | Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1&ndash 4) as well as previously reported metabolites (5&ndash 13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC50 = 3.3 µ M). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra. |
| Databáze: | OpenAIRE |
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