Serum levels of laminin and von Willebrand factor in COVID-19 survivors 6 months after discharge
| Autor: | Qian Wu, Li Li, Zhonghua Qin, Limin Zhang, Yajie Li, Hongwei Li, Guo Jin, Xinwei Hou, Qi Wu, Yan Zhang, Huaiyong Chen, Fangfei Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Chest computed tomography Coronavirus disease 2019 (COVID-19) Infectious and parasitic diseases RC109-216 Lung injury von Willebrand factor Gastroenterology Article Von Willebrand factor Laminin Internal medicine Female patient Humans Medicine Survivors Aged Lung biology SARS-CoV-2 business.industry Follow-up COVID-19 General Medicine After discharge Patient Discharge Infectious Diseases medicine.anatomical_structure Pulmonary diffusion biology.protein Female business |
| Zdroj: | International Journal of Infectious Diseases, Vol 115, Iss, Pp 134-141 (2022) International Journal of Infectious Diseases |
| ISSN: | 1201-9712 |
| Popis: | Objectives: The aim of this study was to evaluate the clinical characteristics, pulmonary diffusion function, chest computed tomography (CT), and serum lung cell damage indicators of coronavirus disease 2019 (COVID-19) survivors 6 months after discharge. Methods: Data of COVID-19 survivors discharged from hospital between January 21, 2020 and January 11, 2021 and healthy controls were collected. Serum levels of surfactant protein D (SP-D)11 ‘Surfactant D’ has been changed to ‘surfactant protein D’ throughout, and ‘SPD’ has been changed to ‘SP-D’. Are these changes correct?, the receptor for advanced glycation end products (RAGE)22 RAGE: ‘receptor for advanced glycation products’ has been changed to ‘receptor for advanced glycation end products’ throughout. Is this correct?, laminin, and von Willebrand factor (vWF) were measured in the healthy controls and COVID-19 survivors 6 months after discharge. The relationships between serum lung cell damage indicator levels and various parameters were explored. Results: Fifty-two COVID-19 survivors (31 with non-severe disease and 21 with severe disease) and 30 controls were included. Serum levels of laminin in COVID-19 survivors 6 months after discharge were significantly higher than those in the controls. The increase was more significant in elderly and female patients. Serum levels of RAGE and vWF were not statistically different from those of the controls. However, 6 months after discharge, COVID-19 survivors with abnormal chest CT and those in the severe group had higher vWF levels. Conclusions: COVID-19 patients had abnormal lung injury indicators 6 months after discharge. The recovery time after infection is currently unknown, and long-term observation is required. |
| Databáze: | OpenAIRE |
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