Nitric Oxide Metabolites as Biomarkers for follow-up after Chronic Rhinosinusitis Surgery
| Autor: | Mohammad R. Ebrahimkhani, Mohsen Naraghi, Ahmad Reza Dehpour, Alain Fabrice Sontou, Armin Farajzadeh Deroee |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Nasal cavity medicine.medical_specialty Adolescent Metabolite Nitric Oxide chemistry.chemical_compound Nasal Polyps otorhinolaryngologic diseases medicine Humans Immunology and Allergy Nasal polyps Sinusitis Nose Pain Measurement Rhinitis business.industry Endoscopy Common cold General Medicine Middle Aged Nasal Lavage Fluid medicine.disease Pathophysiology Surgery Treatment Outcome medicine.anatomical_structure Otorhinolaryngology chemistry Chronic Disease Nasal Lavage Nasal Cavity business Biomarkers Follow-Up Studies |
| Zdroj: | American Journal of Rhinology & Allergy. 23:159-161 |
| ISSN: | 1945-8932 1945-8924 |
| DOI: | 10.2500/ajra.2009.23.3289 |
| Popis: | BackgroundNitric oxide (NO) has a variety of effects on the pathophysiology of the nasal cavity and seems to play an important role in inflammation. It is increased in the common cold but decreased in acute and chronic rhinosinusitis (CRS). Exhaled NO increases after endoscopic sinus surgery in CRS. In our previous study we showed that NO metabolite (nitrate and nitrite) levels are increased in the sinus cavity of CRS patients. We hypothesized that NO metabolite levels are increased to normal in the nasal lavage of CRS patients after endoscopic sinus surgery and NO metabolites in the nasal lavage can be used as indicators of the disease status after surgery.MethodsThis study was performed on 52 patients with CRS who did not respond to medical therapy and who underwent surgery. NO metabolite levels were measured in nasal lavages of the patients before surgery and 2 months after surgery.ResultsNO metabolite levels (mean ± SEM) were 18.11 ± 3.08 μmol/L and 35.97 ± 4.64 μmol/L in nasal lavages of patients before and after surgery, respectively. The levels of NO metabolites were increased significantly (p < 0.01) after surgery in nasal lavages and patients reported significant improvement based on the visual analog scoring after the operation.ConclusionNO metabolite levels were decreased in nasal lavages of CRS patients and were increased to normal levels after surgery along with improvement of the disease. NO metabolite levels may be used as an indicator for the follow-up of patients after endoscopic sinus surgery. |
| Databáze: | OpenAIRE |
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