Association between admission plasma 2-oxoglutarate levels and short-term outcomes in patients with acute heart failure: a prospective cohort study

Autor: Qiong Zhan, Qingchun Zeng, Hanlin Li, Tu Yan, Dingli Xu, Zhengliang Peng, Yujia Bai, Xiangkun Xie, Boxin Zhao, Xingfu Huang, Wenyan Lai
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Molecular Medicine, Vol 25, Iss 1, Pp 1-9 (2019)
Molecular Medicine
ISSN: 1528-3658
1076-1551
DOI: 10.1186/s10020-019-0078-1
Popis: Background 2-oxoglutarate (2OG), an intermediate metabolite in the tricarboxylic acid cycle, has been found to associate with chronic heart failure (HF), but its effect on short-term adverse outcomes in patients with acute HF (AHF) is uncertain. Methods This prospective cohort study included 411 consecutive hospitalized patients with AHF. During hospitalization, fasting plasma samples were collected within the first 24 h of admission. Plasma 2OG levels were measured by hydrophilic interaction liquid chromatography-liquid chromatography tandem mass spectrometry (HILIC-LC/MS/MS). All participants were followed up for six months. Multiple logistic regression was used to determine the odds ratio (OR) and 95% confidence interval (CI) for primary outcomes. Results The AHF cohort consisted of HF with preserved ejection fraction (EF) (64.7%), mid-range EF (16.1%), and reduced EF (19.2%), the mean age was 65 (±13) years, and 65.2% were male. Participants were divided into two groups based on median 2OG levels (μg/ml): low group (
Databáze: OpenAIRE
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