An Atypical Case of Islet Cell Hyperplasia in a Wistar Rat
| Autor: | Rick Perry, Alexandros Papanikolaou, Norimitsu Shirai |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male endocrine system medicine.medical_specialty Pathology endocrine system diseases Injections Subcutaneous Biology Toxicology Pathology and Forensic Medicine Lesion Islets of Langerhans Plasma Islet cells Internal medicine medicine Animals Insulin Rats Wistar Islet cell hyperplasia Molecular Biology Young male Cell Proliferation geography Hyperplasia geography.geographical_feature_category beta-Cyclodextrins Cell Biology Islet medicine.disease 2-Hydroxypropyl-beta-cyclodextrin Rats Endocrinology Toxicity Female medicine.symptom |
| Zdroj: | Toxicologic Pathology. 40:819-822 |
| ISSN: | 1533-1601 0192-6233 |
| DOI: | 10.1177/0192623312441410 |
| Popis: | The present article describes an unusual proliferative islet finding observed incidentally in a young male Wistar rat in a 2-week toxicity study. Histologically, the islet lesion was characterized by diffuse enlargement of the islets, which consisted of peripheral proliferation of non-insulin-containing islet cells surrounding normal-appearing insulin-containing cells in the center. To the authors’ knowledge, this is the first report of spontaneous proliferative islet lesion composed of non-insulin-containing cells in young rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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