Have animal models of disease helped or hindered the drug discovery process?

Autor:	Ann Jacqueline Hunter
Rok vydání:	2011
Předmět:	Mechanism (biology) Drug discovery General Neuroscience Drug Evaluation Preclinical Computational biology Disease Biology Pharmacology General Biochemistry Genetics and Molecular Biology Disease Models Animal History and Philosophy of Science Drug Discovery Animals Humans
Zdroj:	Annals of the New York Academy of Sciences. 1245:1-2
ISSN:	0077-8923
Popis:	Animal models have played an important role in target validation, screening of compounds for efficacy and optimization of pharmacokinetic properties and toxicological testing. However, new paradigms for drug discovery and development will require a greater emphasis on animal models of mechanism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040501def85f7f2bb5041e2b7a895c0e https://doi.org/10.1111/j.1749-6632.2011.06375.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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