A preoperative prognostic model predicting recurrence-free survival for patients with kidney cancer

Autor: Ozgur, Yaycioglu, Saadettin, Eskicorapci, Erdem, Karabulut, Bulent, Soyupak, Cagatay, Gogus, Taner, Divrik, Levent, Turkeri, Sertac, Yazici, Haluk, Ozen, Murat, Bozlu
Přispěvatelé: Çukurova Üniversitesi
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Cancer Research
cancer patient
Multivariate analysis
Time Factors
Survival
medicine.medical_treatment
recurrence free survival
Nephrectomy
medical record review
Medicine
cancer survival
Univariate analysis
adult
article
kidney cancer
General Medicine
Middle Aged
Prognosis
Kidney Neoplasms
Survival Rate
aged
preoperative evaluation
female
Oncology
Predictive value of tests
medicine.medical_specialty
cancer survivor
probability
Preoperative care
cancer prognosis
Predictive Value of Tests
Preoperative Care
Humans
Radiology
Nuclear Medicine and imaging
human
Survival rate
Carcinoma
Renal Cell
Neoplasm Staging
Retrospective Studies
business.industry
cancer staging
prediction
Nomogram
medicine.disease
major clinical study
Surgery
Nomograms
cancer recurrence
age
Neoplasm Recurrence
Local
business
Kidney cancer
Follow-Up Studies
ISSN: 2315-9766
Popis: PubMedID: 23159766 Objective: To develop a preoperative prognostic model in order to predict recurrence-free survival in patients with nonmetastatic kidney cancer. Methods: A multi-institutional data base of 1889 patients who underwent surgical resection between 1987 and 2007 for kidney cancer was retrospectively analyzed. Preoperative variables were defined as age, gender, presentation, size, presence of radiological lymph nodes and clinical stage. Univariate and multivariate analyses of the variables were performed using the Cox proportional hazards regression model. A model was developed with preoperative variables as predictors of recurrence after nephrectomy. Internal validation was performed by Harrell's concordance index. Results: The median follow-up was 23.6 months (1-222 months). During the follow-up, 258 patients (13.7%) developed cancer recurrence. The median follow-up for patients who did not develop recurrence was 25 months. The median time from surgery to recurrence was 13 months. The 5-year freedom from recurrence probability was 78.6%. All variables except age were associated with freedom from recurrence in multivariate analyses (P < 0.05). Age was marginally significant in the univariate analysis. All variables were included in the predictive model. The calculated c-index was 0.747. Conclusions: This preoperative model utilizes easy to obtain clinical variables and predicts the likelihood of development of recurrent disease in patients with kidney tumors. © The Author 2012. Published by Oxford University Press. All rights reserved.
Databáze: OpenAIRE
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