Risk factors for dialysis-associated hepatitis C in Venezuela
| Autor: | Mercedes Zabaleta, Anabella Arminio, Freya I. Capriles, Carmen J. Colmenares, Grete Y. Muller, Irma Machado, Nicolas E. Bianco |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Hepatitis B virus medicine.medical_specialty Adolescent medicine.medical_treatment Hepacivirus medicine.disease_cause Gastroenterology Reference Values Renal Dialysis Risk Factors Internal medicine Prevalence medicine Humans Hepatitis Antibodies Risk factor Dialysis Aged Aged 80 and over biology business.industry Alanine Transaminase Hepatitis C Hepatitis C Antibodies Middle Aged Venezuela biology.organism_classification medicine.disease Alanine transaminase Nephrology Immunology biology.protein Hemodialysis Viral disease business Biomarkers |
| Zdroj: | Kidney International. 41:1055-1058 |
| ISSN: | 0085-2538 |
| Popis: | Risk factors for dialysis-associated hepatitis C in Venezuela. Utilizing the first and second generation of enzyme immunoassays which detect antibodies to the C virus we investigated the frequency of anti-HCV antibodies in 315 patients undergoing hemodialysis. Other subpopulations at risk were used as reference groups. One hundred and twenty-three samples (39%) from the hemodialysis group repeatedly showed anti-HCV positive antibodies while only 19% and 1% were positive in the reference groups. The rate of anti-HCV reactive patients correlated with time on hemodialysis (< 1 year, 17% 1 to 5 years 43% > 5 years, 64% r = 0.94, P < 0.001) and with the number of blood transfusions (1 to 10, 40% > 10, 76% r = 0.97; P < 0.001). Length of time on hemodialysis was shown to be the major risk factor in thirty-three anti-HCV positive patients who had no previous record of blood transfusions. Co-infection with HBV was demonstrated in 41% out of 123 anti-HCV reactive patients, and increased alanine aminotransferase (ALT) activity was documented in this co-infected group. Our results further extend the observations on the predisposing factors to HCV spread in hemodialysis units, and suggest that in these renal patients co-infection with C and B viruses is a major cause of rising ALT activity. |
| Databáze: | OpenAIRE |
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