| Autor: |
Yun-Gang He, Wen-Jing Xie, Shi-Ling Liu, Xiao-Xin Shi, Yong-Kang Huang, Xing-Liang Zhu, Yong-Qiang Luo, Lei Wang |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
ACS Omega, Vol 6, Iss 26, Pp 17103-17112 (2021) |
| ISSN: |
2470-1343 |
| DOI: |
10.1021/acsomega.1c02502 |
| Popis: |
Novel highly stereoselective syntheses of (+)-streptol and (-)-1-epi-streptol starting from naturally abundant (-)-shikimic acid were described in this article. (-)-Shikimic acid was first converted to the common key intermediate by 11 steps in 40% yield. It was then converted to (+)-streptol by three steps in 72% yield, and it was also converted to (-)-1-epi-streptol by one step in 90% yield. In summary, (+)-streptol and (-)-1-epi-streptol were synthesized from (-)-shikimic acid by 14 and 12 steps in 29 and 36% overall yields, respectively. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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