SUPPLEMENTARY Figures and Table from HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells

Autor: Tae Woo Kim, T.C. Wu, Chih-Ping Mao, Minjoo Son, Cassian Yee, Kyung-Mi Lee, Seungki Baek, Stephen M. Hewitt, Joon-Yong Chung, Jae-Hoon Kim, Eun Joo Chung, Hanbyoul Cho, Kyung Hee Noh, Soon-Oh Hong, Seon Rang Woo, Se Jin Oh, Hyo-Jung Lee, Chel Hun Choi, Kwon-Ho Song
Rok vydání: 2023
DOI: 10.1158/0008-5472.22414334.v1
Popis: Supplementary Figure 1. Immune-edited CaSki P3 cells showed a stem-like phenotype. Supplementary Figure 2. NANOG does not effect on acetylation of histone H4. Supplementary Figure 3. Expression of HDAC genes, and genes involved in negative regulators of MCL-1 protein by NANOG-HDAC1 axis. Supplementary Figure 4. The NANOG-HDAC1 axis controls immune-resistance, drug-resistance and stem-like property in multiple types of human cancer cells. Supplementary Figure 5. Generation of MDA-MB231 P3 immune-resistant cell lines. Supplementary Figure 6. Regulation of HAT genes by NANOG-HDAC1 axis. Supplementary Figure 7. Schematic interpretation of immune selection-mediated epigenetic change and implications of epigenetic therapy.
Databáze: OpenAIRE