Impact of Bacille Calmette-Guérin Vaccination on Neuroradiological Manifestations of Pediatric Tuberculous Meningitis
| Autor: | Saad Ajmal, Mohammad Wasay, Ather Taqui, Yousuf Husen, Najam Uddin, Syed Qamaruddin Nizami, Iqbal Azam |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Tuberculosis Severity of Illness Index Tuberculous meningitis Severity of illness medicine Humans Pakistan Child Retrospective Studies business.industry Brain Retrospective cohort study medicine.disease Magnetic Resonance Imaging Surgery Vaccination Treatment Outcome Child Preschool Tuberculosis Meningeal Pediatrics Perinatology and Child Health BCG Vaccine Female Tuberculoma Neurology (clinical) Tomography X-Ray Computed business Meningitis BCG vaccine |
| Zdroj: | Journal of Child Neurology. 25:581-586 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/0883073809340921 |
| Popis: | The authors conducted this study to identify whether bacille Calmette-Guérin (BCG) vaccination leads to an altered spectrum of neuroimaging findings outcome in pediatric patients with tuberculous meningitis. This retrospective study was conducted through chart review and review of computed tomography (CT) scans and magnetic resonance imaging (MRI) of patients with confirmed central nervous system tuberculosis from the year 1992 to 2005, at a large tertiary care hospital in Karachi, Pakistan. A total of 108 pediatric patients with tuberculous meningitis were included in the analysis. Of the 108 patients, 63 (58.3%) were male and 45 (41.7%) had received bacille Calmette-Guérin vaccination. There was no difference in terms of severity of clinical presentation and outcome between vaccinated and unvaccinated group. There were no significant differences in CT or MRI findings between the 2 groups except for tuberculomas on MRI, which were significantly higher in the non—bacille Calmette-Guérin vaccinated group (52.2% vs 22.7%, P = .042). Bacille Calmette-Guérin vaccination appears to translate into less tuberculoma formation on MRI. |
| Databáze: | OpenAIRE |
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