Body Fat distribution, Menopausal Hormone Therapy and Incident Type 2 Diabetes in Postmenopausal Women of the MESA Study
Autor: | Imo A. Ebong, Pamela Ouyang, Kristen G. Hairston, Alain G. Bertoni, Moyses Szklo, Karol E. Watson, Mercedes R. Carnethon |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
Waist medicine.drug_class Type 2 diabetes 030204 cardiovascular system & hematology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine Body Fat Distribution Humans Aged Proportional Hazards Models Gynecology Aged 80 and over 030219 obstetrics & reproductive medicine Proportional hazards model business.industry Incidence Estrogen Replacement Therapy Arizona Obstetrics and Gynecology Middle Aged medicine.disease Postmenopause Diabetes Mellitus Type 2 Estrogen Observational study Female business Body mass index Progestin |
Popis: | Objectives We investigated the association between menopausal hormone therapy (MHT) and incident type 2 diabetes in postmenopausal women, and explored the potential modifying role of body fat distribution on this association. Methods We included 2210 postmenopausal women without prevalent diabetes at recruitment (20002002) from the Multiethnic Study of Atherosclerosis. Cox proportional hazards models were used to examine associations of MHT and MHT types with incident diabetes, testing for variation according to body fat distribution. Results Over a median follow-up of 11.1 years, there were 226 incident cases of diabetes. There were no significant interactions with central or generalized body fatness. In fully adjusted models, current and past MHT use was associated with a greater risk of incident diabetes [HR: 1.66 (1.182.35) and 1.60 (1.112.30) respectively]. Estrogen only (ET) and combined progestin and estrogen (PET) formulations were similarly associated with a greater risk of incident diabetes [HR: 1.52 (1.032.24) and 1.77 (1.152.72) respectively]. Conclusions In our observational study of middle-aged and older, non-diabetic postmenopausal women, a current or past use of MHT was independently associated with a greater risk of incident diabetes. ET and PET are associated with similar risks of incident diabetes in postmenopausal women. The association of MHT use with incident diabetes is the same irrespective of body mass index (BMI) or waist circumference. |
Databáze: | OpenAIRE |
Externí odkaz: |