Aponeocarzinostatin—A superior drug carrier exhibiting unusually high endurance against denaturants
| Autor: | Der-Hang Chin, Christopher G. Sudhahar |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Protein Denaturation
Circular dichroism Magnetic Resonance Spectroscopy Protein Conformation Stereochemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Cell membrane Zinostatin Drug Discovery medicine Enediyne Organic Chemicals Molecular Biology Drug Carriers Chemistry Circular Dichroism Organic Chemistry Nuclear magnetic resonance spectroscopy medicine.anatomical_structure Membrane Drug delivery Biophysics Molecular Medicine Apoproteins Drug carrier Heteronuclear single quantum coherence spectroscopy |
| Zdroj: | Bioorganic & Medicinal Chemistry. 14:3543-3552 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2006.01.012 |
| Popis: | The enediyne antitumor antibiotic chromoproteins are very potent in causing DNA damages. During the drug delivery time course, the stability of the carrier protein becomes an important concern. To simulate conceivably offensive environment in biological contexts, such as cell membrane, we studied structural endurance of aponeocarzinostatin against several denaturants by circular dichroism and nuclear magnetic resonance spectroscopy. For comparison, we also examined proteins known to be stable and similar in size to aponeocarzinostatin. The results highlight the unusual structural stability of aponeocarzinostatin against chemical denaturants, suggesting the potential of aponeocarzinostatin as an inherently superior carrier in drug delivery systems. |
| Databáze: | OpenAIRE |
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