Synthesis of bis(aziridinyl)phosphinyl-N-hydroxyurethane derivatives as antineoplastic agents
| Autor: | Y. Y. Hsiao, Thomas J. Bardos, G. L. Wampler, W. Regelson |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Alkylating Agents
N-hydroxyurethane Azirines Phosphines Stereochemistry Aziridines Drug Evaluation Preclinical Antineoplastic Agents Mice Inbred Strains Aziridine Leukemia L1210 Ring (chemistry) Urethane Lethal Dose 50 Mice chemistry.chemical_compound chemistry Drug Discovery Animals Molecular Medicine Moiety Female |
| Zdroj: | Journal of Medicinal Chemistry. 18:195-198 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00236a019 |
| Popis: | Several new "dual antagonists" were synthesized in which the 2,2-dimethyl (or ring C unsubstituted) aziridine phosphinyl function is linked to N-hydroxyurethane rather than the urethane moiety. Three of the new compounds showed very high activities against leukemia L1210 in mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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