Selective suppression of retroviral gp70-anti-gp70 immune complex formation by prostaglandin E1 in murine systemic lupus erythematosus
| Autor: | Shozo Izui, Patricia J. McConahey, Vicki E. Kelley, Frank J. Dixon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_treatment viruses Immunology Antigen-Antibody Complex Immune complex formation urologic and male genital diseases Immune tolerance chemistry.chemical_compound Mice Viral Proteins Immune system Glomerulonephritis immune system diseases medicine Immune Tolerance Immunology and Allergy Animals Lupus Erythematosus Systemic Prostaglandin E1 skin and connective tissue diseases Glycoproteins biology Prostaglandins E Articles medicine.disease Immune complex Disease Models Animal chemistry Antibodies Antinuclear biology.protein Female Antibody Prostaglandin E |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | The effect of pharmacologic quantities of prostaglandin E1 (PGE) was investigated in three strains of mice (NZB X NZW, MRL/1, and BXSB) that spontaneously develop lupus-like glomerulonephritis. PGE-treatment prolonged survival and retarded the glomerular deposition of immune complex (IC) and the development of glomerulonephritis in NZB X NZW and MRL/1 mice, but did not similarly protect BXSB mice. Changes in the responsive strains correlated well with reduced amounts of circulating gp70 complexed with anti-gp70 antibodies compared with untreated controls, although total concentrations of gp70 (free and complexed) detectable in sera were similar in both groups of mice. The results strongly suggest that: (a) PGE selectively suppressed the immune response to retroviral gp70, (b) PGe had little effect on the quantity or quality of anti-DNA antibodies but did reduce the deposition of anti-DNA containing IC in the kidneys, and (c) gp70 IC appear to play an important role in the pathogenesis of glomerulonephritis in murine systemic lupus erythematosus. |
| Databáze: | OpenAIRE |
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