Effects of hazelnut supplemented diet on doxorubicin-induced damage of reproductive system in male rats
| Autor: | Gökçen Kerimoğlu, Cesarettin Alasalvar, Fulya Balaban Yucesan, Asım Örem, Akın Bodur, Birgül Vanizor Kural, Hanife Kara, Sibel Türedi, Serap Ozer Yaman, Esin Yulug |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Biophysics medicine.disease_cause Antioxidants Lipid peroxidation chemistry.chemical_compound Corylus Internal medicine Testis Medicine Animals Humans Doxorubicin Reproductive system Pharmacology business.industry Vitamin E Cell Biology Epididymis Micronutrient Diet Rats medicine.anatomical_structure Endocrinology chemistry Toxicity business Oxidative stress Food Science medicine.drug |
| Zdroj: | Journal of food biochemistryREFERENCES. 45(11) |
| ISSN: | 1745-4514 |
| Popis: | The present study was objected to investigate the effect of hazelnut supplemented diet on the levels of oxidative stress and fertility parameters against doxorubicin-induced testicular and epididymal tissue damage of male rats. Rats were randomly divided into four groups (each n = 8), namely control group (CG), doxorubicin group (DG), doxorubicin + hazelnut group (DHG), and doxorubicin + vitamin E group (DEG). This is the first study designed using DHG. Doxorubicin was intraperitoneally injected into all diet groups except CG at a dose of 3 mg/kg body weight on days 1, 7, 14, 21, and 28. In addition, DHG was supplemented with a hazelnut diet at a dose of 3 g/kg body weight/day and vitamin E was added to the drinking water of DEG at a dose of 50 mg/kg body weight/day. DHG reversed the side effects of doxorubicin and positively improved the epididymis sperm quality, testicular and epididymal tissue injury, testosterone level, epididymis oxidative stress index, and lipid peroxidation in male rats. These findings suggest that hazelnut has positive effects against doxorubicin dependent damage on male rats and it may be a promising supplement for amelioration of testicular toxicity. PRACTICAL APPLICATIONS: Hazelnut has numerous positive health effects due to its macronutrients, micronutrients, lipid-soluble compounds and bioactive phenolics. Studies have shown that regular consumption of hazelnut may have a positive effect on lipid parameters, oxidative stress, inflammation markers, and endothelial dysfunction in both healthy people and patients with chronic diseases. Although doxorubicin (Adriamycin, DOX) is an antibiotic that has been widely used in cancer treatment for nearly 30 years, it causes organ toxicity including testicular tissue. Hazelnut may have positive effects on the damage caused by DOX in the reproductive system. However, studies on the effect of hazelnut on male reproductive health are scarce. Therefore, this study provided a basis for the clinical evaluation of the effects of hazelnut on the reproductive system. |
| Databáze: | OpenAIRE |
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