Online registry for nationwide database ofHelicobacter pylorieradication in Korea: Correlation of antibiotic use density with eradication success

Autor: Sang Gyun Kim, Il Kwun Chung, Seong Woo Jeon, Byung-Wook Kim, Ji Hyun Kim, Joongyub Lee, Tae Ho Kim, Il Ju Choi, Gwang Ho Baik, Gwang Ha Kim, Jae G. Kim, Hyun Joo Song, Chang Hun Yang, Beom Jin Kim, Sue K. Park, Hyang Eun Seo, Moo In Park, Hyun Soo Kim, Ki Nam Shim, Sok Won Han, Jung Hwan Oh, Byung Joo Park, Jun Haeng Lee, Bo Ram Yang, Woon Tae Jung
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Databases
Factual
medicine.drug_class
Antibiotics
macromolecular substances
Helicobacter Infections
antibiotic use
03 medical and health sciences
0302 clinical medicine
Internal medicine
Clarithromycin
Concomitant Therapy
medicine
Humans
Prospective Studies
Registries
Adverse effect
Prospective cohort study
Aged
Aged
80 and over
Internet
Korea
Helicobacter pylori
biology
business.industry
Gastroenterology
first‐line therapy
Original Articles
online registry
General Medicine
Middle Aged
Amoxicillin
biology.organism_classification
Drug Utilization
Anti-Bacterial Agents
Treatment Outcome
Infectious Diseases
Defined daily dose
eradication success
030220 oncology & carcinogenesis
Female
Original Article
030211 gastroenterology & hepatology
business
medicine.drug
Zdroj: Helicobacter
ISSN: 1523-5378
1083-4389
DOI: 10.1111/hel.12646
Popis: Background The Helicobacter pylori eradication rate has decreased with increasing antibiotic resistance. We conducted a prospective, nationwide, multicenter registry study to monitor the real status of H. pylori eradication therapy and to investigate the association between eradication success and antibiotic use density in Korea. Materials and Methods We enrolled 9318 patients undergoing H. pylori eradication therapy from 37 hospitals through “on‐line database registry” from October 2010 to July 2015. Demographic data, detection methods, treatment indications, regimens, durations, compliance, adverse events, and eradication results were collected. The use of all commercially available eradication antibiotics was analyzed through the Korean National Health Insurance data of the Health Insurance Review and Assessment Service. The defined daily dose of antibiotics was used to standardize drug use comparisons. Results Finally, 6738 patients were analyzed. The overall eradication rate of first‐line therapy was 71.8%. The eradication success rates were 71.7%, 86.9%, and 74.0% for standard triple therapy for 7 days, quadruple therapy, and concomitant therapy, respectively. The eradication success rate in naive patients was higher than that in those who previously underwent H. pylori eradication. Eradication success was significantly associated with younger age, female sex, and high compliance. Regional differences in eradication rates were observed. The yearly use density of clarithromycin increased statistically in seven regions across the country from 2010 to 2015. The yearly use density of amoxicillin in the Gyeongsang and Chungcheong areas was significantly increased (P
Databáze: OpenAIRE
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