A biological tube technique for the repair of peripheral nerve defects using 'stuffed nerves'
| Autor: | Bekir Ugur Ergur, Mustafa Akhisaroğlu, Ali Abdülkadir Bacakoğlu, Sercan Çapkın |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Transplants Vein graft Neurosurgical Procedures 03 medical and health sciences 0302 clinical medicine Peripheral nerve Peripheral Nerve Injuries medicine Animals 030212 general & internal medicine Axon Rats Wistar business.industry Regeneration (biology) Anatomy Sciatic Nerve Nerve Regeneration Rats Electrophysiology 030104 developmental biology Anesthesiology and Pain Medicine medicine.anatomical_structure Latency stage Myelin sheath Emergency Medicine Surgery Sciatic nerve business |
| Zdroj: | Ulusal travma ve acil cerrahi dergisi = Turkish journal of traumaemergency surgery : TJTES. 23(1) |
| ISSN: | 1306-696X |
| Popis: | BACKGROUND Presently described is research examining the "stuffed nerve" technique to repair peripheral nerve defects. METHODS Twenty-one male Wistar Albino rats were divided into 3 groups of 7, and standard 10-mm defects were created in the sciatic nerve of all subjects. Rats were treated with autogenous nerve graft (Group 1), hollow vein graft (Group 2), or vein graft stuffed with shredded nerves (Group 3). After 12 weeks, electrophysiological and histomorphological analyses were performed to evaluate axonal regeneration. RESULTS Rat groups were compared in terms of latency period and peak-to-peak potential. Latency period was significantly shorter and peak-to-peak potential was significantly greater in Group 1 than in Group 2. However, latency period and peak-to-peak potential did not differ significantly between Groups 1 and 3 or between Groups 2 and 3. To evaluate axonal regeneration, number of axons, axon diameter and myelin sheath thickness was compared between groups. Results indicated that axonal regeneration was similar in Groups 1 and 3, and was better than results seen in Group 2. CONCLUSION The stuffed nerve technique is an alternative to autogenous nerve grafting and produces similar electrophysiological and histomorphological properties. |
| Databáze: | OpenAIRE |
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