Liposomal amphotericin B (AmBisome) reduces dissemination of infection ad compared with amphotericin B deoxycholate (Fungizone) in a rat model of pulmonary aspergillosis
| Autor: | Irma A. J. M. Bakker-Woudenberg, A. C. A. P. Leenders, M. T. ten Kate, H. A. Verbrugh, S. de Marie |
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| Rok vydání: | 1996 |
| Předmět: |
Microbiology (medical)
Antifungal Agents medicine.medical_treatment Pharmacology Aspergillosis Aspergillus fumigatus Amphotericin B Amphotericin B deoxycholate medicine Animals Pharmacology (medical) Mycosis Chemotherapy Lung Lung Diseases Fungal biology business.industry Respiratory disease medicine.disease biology.organism_classification Rats Disease Models Animal Drug Combinations Infectious Diseases medicine.anatomical_structure Liposomes Immunology business Agranulocytosis Deoxycholic Acid medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 38:215-225 |
| ISSN: | 1460-2091 0305-7453 |
| Popis: | The efficacy of AmBisome, a liposomal formulation of amphotericin B, was compared with that of Fungizone (amphotericin B desoxycholate), in a rat model of unilateral, pulmonary aspergillosis. Repeated administration of cyclophosphamide resulted in persistent, severe granulocytopenia. The left lung was inoculated with a conidial suspension of Aspergillus fumigatus, thus establishing an unilateral infection. Antifungal treatment was started 40 h after fungal inoculation, at which time mycelial disease was confirmed by histological examination. Both Fungizone 1 mg/kg and AmBisome 10 mg/kg resulted in increased survival in terms of delayed as well as reduced mortality. Quantitative cultures of lung tissue showed that only AmBisome 10 mg/kg resulted in reduction of the number of fungal cfus in the inoculated left lung. Compared with Fungizone, both AmBisome 1 mg/kg/day and AmBisome 10 mg/kg/day significantly prevented dissemination from the infected left lung to the right lung. In addition, both AmBisome regimens reduced hepatosplenic dissemination, and the 10 m/kg dosage fully prevented this complication. In conclusion, when compared with Fungizone, in this model AmBisome is more effective in reducing dissemination of unilateral, pulmonary aspergillosis, even when given in relatively low dosage. Such low dosages may have a place in prophylactic settings. |
| Databáze: | OpenAIRE |
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