Functional MRI-navigated Repetitive Transcranial Magnetic Stimulation Over Supplementary Motor Area in Chronic Tic Disorders
| Autor: | David A. Huddleston, Paul S. Horn, Stephan G. Dixon, Thomas Maloney, Donald L. Gilbert, Steve W. Wu, Kenneth P. Eaton, Jennifer Vannest |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Tics Adolescent Plasticity medicine.medical_treatment Repetitive transcranial magnetic stimulation CTBS Biophysics Audiology Tourette syndrome lcsh:RC321-571 Young Adult Double-Blind Method Theta burst stimulation mental disorders medicine Humans Child lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Supplementary motor area General Neuroscience Motor Cortex medicine.disease SMA Magnetic Resonance Imaging Transcranial Magnetic Stimulation Transcranial magnetic stimulation medicine.anatomical_structure Treatment Outcome Attention Deficit Disorder with Hyperactivity Tic Disorders Finger tapping Female Neurology (clinical) Primary motor cortex Psychology Neuroscience |
| Zdroj: | Brain Stimulation, Vol 7, Iss 2, Pp 212-218 (2014) |
| Popis: | Background: Open label studies have shown repetitive transcranial magnetic stimulation to be effective in reducing tics. Objectives: To determine whether 8 sessions of continuous theta burst stimulation (cTBS) over supplementary motor area (SMA) given over 2 days may reduce tics and motor cortical network activity in Tourette syndrome/chronic tic disorders. Methods: This was a randomized (1:1), double-blind, sham-controlled trial of functional MRI (fMRI)-navigated, 30 Hz cTBS at 90% of resting motor threshold (RMT) over SMA in 12 patients ages 10–22 years. Comorbid ADHD (n = 8), OCD (n = 8), and stable concurrent medications (n = 9) were permitted. Neuro-navigation utilized each individual's event-related fMRI signal. Primary clinical and cortical outcomes were: 1) Yale Global Tic Severity Scale (YGTSS) at one week; 2) fMRI event-related signal in SMA and primary motor cortex (M1) during a finger-tapping motor task. Result: Baseline characteristics were not statistically different between groups (age, current tic/OCD/ADHD severities, tic-years, number of prior medication trials, RMT). Mean YGTSS scores decreased in both active (27.5 ± 7.4 to 23.2 ± 9.8) and sham (26.8 ± 4.8 to 21.7 ± 7.7) groups. However, no significant difference in video-based tic severity rating was detected between the two groups. Two-day post-treatment fMRI activation during finger tapping decreased significantly in active vs. sham groups for SMA (P = 0.02), left M1 (P = 0.0004), and right M1 (P |
| Databáze: | OpenAIRE |
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