Abdominal Ultrasound Does Not Reveal Significant Alterations in Patients With Nonceliac Wheat Sensitivity
| Autor: | Antonino Terranova, Francesca Cavataio, Alberto D'Alcamo, Maurizio Soresi, Antonio Carroccio, Rosario Iacobucci, Francesco La Blasca, Pasquale Mansueto |
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| Přispěvatelé: | Soresi, Maurizio, Mansueto, Pasquale, Terranova, Antonino, D'Alcamo, Alberto, La Blasca, Francesco, Cavataio, Francesca, Iacobucci, Rosario, Carroccio, Antonio |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Non-Celiac Wheat sensitivity Celiac Disease Abdominal Ultrasound Seronegative celiac disease Double-blind placebo-controlled challenge Settore MED/09 - Medicina Interna Glutens Wheat Hypersensitivity Gastroenterology 030218 nuclear medicine & medical imaging Diagnosis Differential Irritable Bowel Syndrome Diet Gluten-Free Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method Internal medicine Elimination diet Abdomen Ascites medicine Humans Mesenteric lymph nodes Prospective Studies Prospective cohort study Irritable bowel syndrome Ultrasonography business.industry Ultrasound Middle Aged medicine.disease Celiac Disease medicine.anatomical_structure Female 030211 gastroenterology & hepatology Gluten free medicine.symptom Differential diagnosis business |
| Popis: | GOALS: The goal of this study was (A) to evaluate abdominal ultrasound signs in nonceliac wheat sensitivity (NCWS) patients for features useful in diagnosis and (B) to compare these aspects with those of celiac patients to assess whether ultrasound can be useful in the differential diagnosis between NCWS and celiac disease (CD). BACKGROUND: NCWS diagnosis is difficult as no biomarkers of this condition have as yet been identified. In CD ultrasound aspects have been identified that have a good diagnostic accuracy. STUDY: We prospectively recruited 45 NCWS patients (11 males, 34 females; mean age 35.7 y). Three control groups were included: (A) 99 age-matched CD patients; (B) 18 patients with seronegative CD; (C) 50 patients with irritable bowel syndrome (IBS) who did not improve on a wheat-free diet. NCWS diagnosis was confirmed on the basis of an elimination diet and double-blind placebo-controlled (DBPC) challenge. Ultrasound sign investigation included: dilatation of the small bowel loops, thickening of the small bowel wall, hyperperistalsis, enlarged mesenteric lymph nodes, ascites, hyposplenism, altered diameter of the portal vein. RESULTS: NCWS patients showed a low frequency of pathologic ultrasound findings. Dilated or thickened loops appeared more often in CD patients than in NCWS patients (88.8% vs. 20%; P |
| Databáze: | OpenAIRE |
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