Human monoclonal Fab and human plasma antibodies to carbamyl-epitopes cross-react with malondialdehyde-adducts

Autor:	Piotr Prus, S. Pauliina Turunen, Jaakko Lehtimäki, Chunguang Wang, Sohvi Hörkkö, Marja Veneskoski, Outi Kummu
Rok vydání:	2014
Předmět:	Phage display T-Lymphocytes Immunology Apoptosis Acetaldehyde Cross Reactions Binding Competitive Epitope Epitopes Immunoglobulin Fab Fragments Jurkat Cells Mice chemistry.chemical_compound Malondialdehyde Animals Humans Immunology and Allergy Autoantibodies biology Macrophages Antibodies Monoclonal Original Articles Atherosclerosis Immunity Humoral Lipoproteins LDL Disease Models Animal chemistry Biochemistry Low-density lipoprotein Monoclonal biology.protein lipids (amino acids peptides and proteins) Antibody Cell Surface Display Techniques Clone (B-cell biology) Oxidation-Reduction Lipoprotein
Zdroj:	Immunology. 141:416-430
ISSN:	0019-2805
Popis:	Summary Oxidized low-density lipoprotein (OxLDL) plays a crucial role in the development of atherosclerosis. Carbamylated LDL has been suggested to promote atherogenesis in patients with chronic kidney disease. Here we observed that plasma IgG and IgM antibodies to carbamylated epitopes were associated with IgG and IgM antibodies to oxidation-specific epitopes (ρ = 0·65–0·86, P
Databáze:	OpenAIRE
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