Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism
| Autor: | Patricia Noemi Vidal, Víctor Castillo, María Fernanda Cabrera Batter, Omar Pedro Pignataro, D. D. Miceli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Dyslipidaemia endocrine system diseases medicine.medical_treatment Adipose tissue 030209 endocrinology & metabolism Hyperadrenocorticism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus medicine Dyslipidaemia Hyperadrenocorticism Insulin resistance Metformin Creatinine General Veterinary business.industry Ciencias Veterinarias Insulin nutritional and metabolic diseases medicine.disease Metformin 030104 developmental biology Endocrinology chemistry QL1-991 CIENCIAS AGRÍCOLAS Homeostatic model assessment purl.org/becyt/ford/4.3 [https] business Hyperinsulinism Zoology purl.org/becyt/ford/4 [https] medicine.drug |
| Zdroj: | Open Veterinary Journal, Vol 8, Iss 2, Pp 193-199 (2018) Open Veterinary Journal; Vol 8, No 2 (2018); 193-199 CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 2218-6050 2226-4485 |
| Popis: | Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia,dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of theskeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control ofmetabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly dividedinto two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h). Both groupsreceived the same treatment for HAC. At baseline and 3 months, blood glucose, total cholesterol, triglycerides andinsulin concentrations, in addition to urinary cortisol:creatinine ratio, Homeostatic Model Assessment (HOMA) forinsulin sensitivity and β-cell function were measured. Dogs treated with metformin showed significantly reducedglycaemia, cholesterolaemia and triglyceridaemia. They also presented reduced hyperinsulinism and insulinresistance, as well as improved pancreatic β-cell function. The implementation of metformin as an adjuvant therapyis effective for the normalisation of metabolic disorders of dogs with HAC. Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Vidal, Patricia Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina Fil: Cabrera Batter, María Fernanda. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina Fil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Medicina. Clínica Medica de Animales Pequeños; Argentina |
| Databáze: | OpenAIRE |
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