Potentiation of the Anti-Inflammatory and Analgesic Activity of Aspirin by Caffeine in the Rat
| Autor: | R, Vinegar, J F, Truax, J L, Selph, R M, Welch, H L, White, C H, Ellis |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.drug_class Indomethacin Analgesic Prostaglandin Pharmacology General Biochemistry Genetics and Molecular Biology Anti-inflammatory Arthritis Rheumatoid chemistry.chemical_compound Caffeine Phenylbutazone Animals Medicine Cyclooxygenase Inhibitors Sodium salicylate Inflammation Aspirin business.industry Salicylates Rats chemistry Hyperalgesia Drug Therapy Combination medicine.symptom business medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 151:556-560 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-151-39257 |
| Popis: | Caffeine has been found to potentiate the acute anti-inflammatory activity of aspirin, indomethacin, and phenylbutazone, but not the activity of sodium salicylate or hydrocortisone, in the carrageenan pleurisy or hindlimb models of inflammation in the rat. The mobilization of inflammatory cells was not affected by aspirin in the presence or absence of caffeine. The mild analgesia produced by aspirin was confined to a hyperalgesic test in which this drug was able to reduce inflammation and concomitant hyperalgesia and thereby produce an "apparent" analgesic effect. This "apparent" analgesia produced by aspirin was potentiated by caffeine. The mechanism responsible for the potentiated anti-inflammatory and mild analgesic activity of aspirin remains unknown since caffeine did not alter the plasma salicylate levels or prostaglandin synthetase inhibition produced by aspirin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|