Magnetic aerosol drug targeting in lung cancer therapy using permanent magnet
| Autor: | Mozhgan Naseh, Amir Sanati-Nezhad, Milad Shamsi, Mahsa Saadat, Mehdi Mohammadi, Reza Kamali, Mohammad K.D. Manshadi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Lung Neoplasms Magnetic Field Therapy Pharmaceutical Science Antineoplastic Agents 02 engineering and technology 030226 pharmacology & pharmacy Models Biological 03 medical and health sciences Magnetics permanents magnet 0302 clinical medicine Drug Delivery Systems medicine Humans Lung cancer Lung aerosol drug targeting Aerosols Tumor size lcsh:RM1-950 General Medicine respiratory system 021001 nanoscience & nanotechnology medicine.disease Microspheres Aerosol lung cancer bronchial tumor medicine.anatomical_structure lcsh:Therapeutics. Pharmacology Targeted drug delivery Magnet Drug delivery Magnets computational fluid dynamics (cfd) 0210 nano-technology human activities Biomedical engineering Particle deposition Research Article |
| Zdroj: | Drug Delivery, Vol 26, Iss 1, Pp 120-128 (2019) Drug Delivery |
| ISSN: | 1521-0464 1071-7544 |
| Popis: | Primary bronchial cancer accounts for almost 20% of all cancer death worldwide. One of the emerging techniques with tremendous power for lung cancer therapy is magnetic aerosol drug targeting (MADT). The use of a permanent magnet for effective drug delivery in a desired location throughout the lung requires extensive optimization, but it has not been addressed yet. In the present study, the possibility of using a permanent magnet for trapping the particles on a lung tumor is evaluated numerically in the Weibel's model from G0 to G3. The effect of different parameters is considered on the efficiency of particle deposition in a tumor located on a distant position of the lung bronchi and bronchioles. Also, the effective position of the magnetic source, tumor size, and location are the objectives for particle deposition. The results show that a limited particle deposition occurs on the lung branches in passive targeting. However, the incorporation of a permanent magnet next to the tumor enhanced the particle deposition fraction on G2 to up to 49% for the particles of 7 µm diameter. Optimizing the magnet size could also improve the particle deposition fraction by 68%. It was also shown that the utilization of MADT is essential for effective drug delivery to the tumors located on the lower wall of airway branches given the dominance of the air velocity and resultant drag force in this region. The results demonstrated the high competence and necessity of MADT as a noninvasive drug delivery method for lung cancer therapy. |
| Databáze: | OpenAIRE |
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