Logical Knowledge Representation of Regulatory Relations in Biomedical Pathways
| Autor: | Sine Zambach, Jens Ulrik Hansen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Open Biomedical Ontologies
Knowledge-based systems Knowledge extraction Commonsense knowledge Knowledge representation and reasoning Computer science Systems biology Open Knowledge Base Connectivity Semantic analysis (knowledge representation) Web Ontology Language Data science computer computer.programming_language |
| Zdroj: | Information Technology in Bio-and Medical Informatics, ITBAM 2010 ISBN: 9783642150197 ITBAM Roskilde University |
| DOI: | 10.1007/978-3-642-15020-3_17 |
| Popis: | Knowledge on regulatory relations, in for example regulatory pathways in biology, is used widely in experiment design by biomedical researchers and in systems biology. The knowledge has typically either been represented through simple graphs or through very expressive differential equation simulations of smaller sections of a pathway. As an alternative, in this work we suggest a knowledge representation of the most basic relations in regulatory processes regulates, positively regulates and negatively regulates in logics based on a semantic analysis. We discuss the usage of these relations in biology and in artificial intelligence for hypothesis development in drug discovery. |
| Databáze: | OpenAIRE |
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