Efficacy of desmopressin in patients with multiple sclerosis suffering from bladder dysfunction: a meta-analysis
Autor: | E. Havlikova, Klaske Wynia, Berry Middel, R Bosma, de Jacques Keyser |
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Přispěvatelé: | Gerontology, Science in Healthy Ageing & healthcaRE (SHARE), Public Health Research (PHR) |
Rok vydání: | 2005 |
Předmět: |
Male
desmopressin Renal Agents Enuresis Multiple Sclerosis/*complications/physiopathology Deamino Arginine Vasopressin Non-U.S. Gov't Desmopressin ENURESIS Sodium/blood Urination/drug effects/physiology General Medicine Water-Electrolyte Balance Middle Aged Treatment Outcome Deamino Arginine Vasopressin/*pharmacology/therape Neurology Meta-analysis Female medicine.symptom hormones hormone substitutes and hormone antagonists medicine.drug Adult medicine.medical_specialty Multiple Sclerosis Neurogenic/*drug therapy/*etiology/physiopathology NOCTURIA Bladder Urology bladder dysfunction Urination Research Support Mean difference Central nervous system disease urinary frequency Renal Agents/*pharmacology/therapeutic use MANAGEMENT medicine Humans Nocturia In patient Urinary Bladder Neurogenic Aged business.industry Multiple sclerosis Sodium Osmolar Concentration medicine.disease Surgery Water-Electrolyte Balance/drug effects/physiology Neurology (clinical) business |
Zdroj: | Acta neurologica Scandinavica, 112(1), 1-5. Wiley |
ISSN: | 1600-0404 0001-6314 |
Popis: | Objectives - The current review evaluates the safety and efficacy of desmopressin in patients with multiple sclerosis (MS) who suffer from both daytime and nocturnal voiding frequency and from incontinence. Materials and methods -A literature search was carried out looking for studies published between 1990 and 2003 which evaluated desmopressin in MS patients with bladder dysfunction. Results - The grand total mean effect sizes show the following, estimates of clinical relevant differences: desmopressin has a moderate effect on the number of voids during the day or during the night over a period of 6 h after taking the drug. A large effect associated with the use of desmopressin was detected by the mean difference in urine volume (ml) in 6 h. A small effect was detected in the mean 24-h urine volume. Serum sodium levels were combined with plasma onsmolality in some studies and were found to be not significantly affected by desmopressin treatment. |
Databáze: | OpenAIRE |
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