Efficacy of desmopressin in patients with multiple sclerosis suffering from bladder dysfunction: a meta-analysis

Autor: E. Havlikova, Klaske Wynia, Berry Middel, R Bosma, de Jacques Keyser
Přispěvatelé: Gerontology, Science in Healthy Ageing & healthcaRE (SHARE), Public Health Research (PHR)
Rok vydání: 2005
Předmět:
Male
desmopressin
Renal Agents
Enuresis
Multiple Sclerosis/*complications/physiopathology
Deamino Arginine Vasopressin
Non-U.S. Gov't
Desmopressin
ENURESIS
Sodium/blood
Urination/drug effects/physiology
General Medicine
Water-Electrolyte Balance
Middle Aged
Treatment Outcome
Deamino Arginine Vasopressin/*pharmacology/therape
Neurology
Meta-analysis
Female
medicine.symptom
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Adult
medicine.medical_specialty
Multiple Sclerosis
Neurogenic/*drug therapy/*etiology/physiopathology
NOCTURIA
Bladder
Urology
bladder dysfunction
Urination
Research Support
Mean difference
Central nervous system disease
urinary frequency
Renal Agents/*pharmacology/therapeutic use
MANAGEMENT
medicine
Humans
Nocturia
In patient
Urinary Bladder
Neurogenic
Aged
business.industry
Multiple sclerosis
Sodium
Osmolar Concentration
medicine.disease
Surgery
Water-Electrolyte Balance/drug effects/physiology
Neurology (clinical)
business
Zdroj: Acta neurologica Scandinavica, 112(1), 1-5. Wiley
ISSN: 1600-0404
0001-6314
Popis: Objectives - The current review evaluates the safety and efficacy of desmopressin in patients with multiple sclerosis (MS) who suffer from both daytime and nocturnal voiding frequency and from incontinence. Materials and methods -A literature search was carried out looking for studies published between 1990 and 2003 which evaluated desmopressin in MS patients with bladder dysfunction. Results - The grand total mean effect sizes show the following, estimates of clinical relevant differences: desmopressin has a moderate effect on the number of voids during the day or during the night over a period of 6 h after taking the drug. A large effect associated with the use of desmopressin was detected by the mean difference in urine volume (ml) in 6 h. A small effect was detected in the mean 24-h urine volume. Serum sodium levels were combined with plasma onsmolality in some studies and were found to be not significantly affected by desmopressin treatment.
Databáze: OpenAIRE
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