A focused evaluation of lumbar spine trabecular bone score in the first year post-menarche

Autor: Tamara A. Scerpella, Neil Binkley, Jodi N. Dowthwaite, R Winzenrieth, Diane Krueger
Rok vydání: 2017
Předmět:
Zdroj: Archives of osteoporosis. 12(1)
ISSN: 1862-3514
Popis: Trabecular bone score, an index of lumbar spine trabecular texture, has not been explored fully in adolescent girls. Our cross-sectional analysis supported the hypothesis that “adult normal” trabecular bone score has been achieved by the end of the first year post-menarche, providing a potential screening tool, independent from bone density. Trabecular bone score (TBS) evaluates lumbar spine (LS) trabecular texture from DXA images. Limited evidence suggests low TBS in pre-pubertal girls. TBS has not been assessed in the context of the key peri-menarcheal bone accrual phase. Thus, we evaluated (1) whether “normal” adult TBS (≥ 1.35) is reached in the first year post-menarche and (2) the role of maturational timing (menarcheal age) and status (gynecological age) in TBS variation. For 44 healthy girls aged 11 to 13 years, whole body and LS DXA scans were obtained within 1 year post-menarche. As TBS is optimized for adults and can be affected by body thickness, custom software provided unadjusted “rawTBS” and adjusted for tissue thickness “corrTBS” (TBS iNsight, Medimaps, France). Correlations evaluated menarcheal age and gynecological age as factors in LS bone mineral content (BMC), areal bone mineral density (BMD), and TBS. Lowest observed TBS exceeded 1.35 (rawTBS = 1.362; corrTBS = 1.352). Menarcheal age correlated negatively with rawTBS (r = − 0.34, p = 0.02), with a similar trend for corrTBS (r = − 0.29, p
Databáze: OpenAIRE
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