Distribution of gamma delta T-cells in the bronchial tree of smokers and non-smokers
| Autor: | T Ashcroft, P A Corris, G E Pritchard, E H Walters, I Richmond |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Delta Pathology medicine.medical_specialty Adolescent CD3 Population Bronchi Epithelium Pathology and Forensic Medicine Leukocyte Count T-Lymphocyte Subsets Submucosa medicine Humans education Aged education.field_of_study Lung biology business.industry Smoking T-cell receptor Receptors Antigen T-Cell gamma-delta General Medicine T lymphocyte Middle Aged respiratory system respiratory tract diseases medicine.anatomical_structure Immunology biology.protein Immunohistochemistry Female business Research Article |
| Zdroj: | Journal of Clinical Pathology. 46:926-930 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.46.10.926 |
| Popis: | AIMS--To assess the distribution of gamma delta T-cells in the human bronchial tree; and to compare quantitatively the differences between gamma delta T-cell numbers in different parts of the airway wall in smokers and non-smokers. METHODS--Full thickness bronchial wall sections were taken from 10 whole lung specimens from both smokers and non-smokers. Serial cryostat sections stained with the monoclonal antibodies CD3 and TCR delta-1 were examined with the aid of interactive image analysis to assess gamma delta T-cell numbers both in absolute terms and as a proportion of total T lymphocyte numbers. RESULTS--In all cases gamma delta T-cells were demonstrable throughout the airway wall. Although in absolute terms they tend to occur predominantly in the bronchial epithelium, this seems to reflect higher numbers of T lymphocytes in the epithelium in general compared with the submucosa. No genuine epitheliotropism is evident. Comparison by smoking status shows a significant increase in gamma delta T-cell numbers in the bronchial glands of smokers compared with non-smokers. CONCLUSIONS--gamma delta T-cells form an integral though variable component of the immunocompetent cell population of the human airway in both smokers and non-smokers. Although epitheliotropism does not exist in the bronchial tree, gamma delta T-cells seem to form a significant part of the bronchial gland inflammation associated with smoking. |
| Databáze: | OpenAIRE |
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