Highly atom efficient synthesis of 2,2,4,5-tetrasubstituted 3(2H)-furanones having both hydroxyl and amino substituents

Autor: Jesna Antony, Sumi P. Musthafa, Rakesh Natarajan, Sindhu Mathai, Karakkattu S. Devaky, John P. Rappai
Rok vydání: 2022
Předmět:
DOI: 10.6084/m9.figshare.19152988.v1
Popis: We have developed a highly atom efficient synthesis of tetrasubstituted 3(2H)-furanones from easily accessible starting materials such as C,N-diarylaldonitrones and dibenzoylacetylene. Control experiments revealed that reaction of aldonitrones having electron-withdrawing groups on the C-aryl substituent in polar aprotic solvents exhibited high product selectivity while reaction temperature has only a negligible effect on product yield and selectivity.
Databáze: OpenAIRE